KANEKA NUTRIENTS L.P. : Clinical Trials

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Since Coenzyme Q10’s discovery in 1957, researchers worldwide have found many promising uses for the nutrient. Studies have shown that CoQ10 not only plays a pivotal role in cellular health and energy production, but also may help alleviate the effects of a number of diseases and conditions.

For a full listing of clinical abstracts and articles about CoQ10, visit the National Center for Biotechnology Information.

For listing of journal articles about CoQ10 pertaining to specific diseases,
see the following pages:

Aging	Heart Disease
Alzheimer's Disease	High Blood Pressure (Hypertension)
Amyotrophic Lateral Sclerosis (ALS)	Huntington's Disease
Antioxidant Function	Immune System
Atherosclerosis	Muscular Dystrophy
Cancer	Parkinson's Disease
Diabetes	Periodontal Disease
Energy	Statins
Friedreich’s Ataxia	Sporting Activity

Aging

Field

Title

Author

Journal

1	Human aging and global function of coenzyme Q10.	Linnane AW, et al.	Ann. N. Y. Acad. Sci. 2002; 959:396-411
2	Role of mitochondria in oxidative stress and aging	Lenaz G, et al.	Ann. N. Y. Acad. Sci. 2002; 959:199-213
3	Coenzyme Q10, a cutaneous antioxidant and energizer.	Hoppe U, et al.	Biofactors. 1999; 9(2-4):371-8
4	Mitochondrial aging: open questions.	Beckman KB, et al.	Ann. N. Y. Acad. Sci. 1998; 854:118-27
5	Age-related changes in the lipid compositions of rat and human tissues.	Kalen A, et al.	Lipids. 1989; 24(7):579-84

Altzheimer's Disease

Field

Title

Author

Journal

1	Serum levels of coenzyme Q10 in patients with Alzheimer's disease.	de Bustos F, et al.	J. Neural Transm. 2000; 107(2):233-9
2	Muscle biopsy in Alzheimer's disease: morphological and biochemical findings.	Mariani C, et al.	Clin. Neuropathol. 1991; 10(4): 171-6

Amyotrophic Lateral Sclerosis (ALS)
Lou Gehrig's Disease

Field

Title

Author

Journal

1	Coenzyme Q10 as a possible treatment for neurodegenerative disease.	Beal MF.	Free Radic. Res. 2002; 36(4): 455-60
2	Serum levels of coenzyme Q10 in patients with amyotrophic lateral sclerosis.	Molina JA, et al.	J. Neural Transm. 2000; 107 (8-9):1021-6
3	Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects.	Matthews RT, et al.	Proc. Natl. Acad. Sci. U. S. A. 1998; 95(15):8892-7

Antioxidant Function

Field

Title

Author

Journal

1	Effect of dicumarol, a NAD(P)H: quinone acceptor oxido-reductase (DT-diaphorase) inhibitor on ubiquinone redox cycling in cultured rat hepatocytes.	Kishi T, et al.	Free Radic. Res. 2002; 36(4): 413-9
2	Mechanisms of antioxidant action of ubiquinol-10 for low- density lipoprotein.	Thomas SR, et al.	in Coenzyme Q: Molecular Mechanism 2001; 131-150
3	Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes.	Tomasetti M, et al.	Free Radic. Biol. Med. 1999; 27(9-10):1027-32
4	Expansion of antioxidant function of vitamin E by coenzyme Q.	Quinn PJ, et al.	Biofactors. 1999; 9(2-4):149-154
5	Biochemical, physiological and medical aspects of ubiquinone function.	Ernster L, et al.	Biochim. Biophys. Acta. 1995; 1271(1):195-204
6	Antioxidative effect of dietary coenzyme Q10 in human blood plasma.	Weber C, et al.	Int. J. Vitam. Nutr. Res. 1994; 64(4):311-5

Atherosclerosis

Field

Title

Author

Journal

1	Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice.	Thomas SR, et al.	Arterioscler. Thromb. Vasc. Biol. 2001; 21(4):585-93
2	Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice.	Witting PK, et al.	Free Radic. Biol. Med. 2000; 29(3-4):295-305
3	Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation.	Mohr D, et al.	Biochem. Biophys. Acta. 1992; 1126(3):247-54

Cancer

Field

Title

Author

Journal

1	Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients.	Portakal O, et al.	Clin. Biochem. 2000; 33(4):279-84
2	CoQ10: could it have a role in cancer management?	Hodges S, et al.	Biofactors. 1999; 9(2-4):365-70
3	Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer.	Folkers K, et al.	Biochem. Biophys. Res.. Commun. 1997; 234(2):296-9
4	Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases.	Lockwood K, et al.	Biochem. Biophys. Res. Commun. 1995; 212(1):172-7
5	Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10.	Lockwood K, et al.	Biochem. Biophys. Res. Commun. 1994; 199(3):1504-8
6	Survival of cancer patients on therapy with coenzyme Q10.	Folkers K, et al.	Biochem. Biophys. Res. Commun. 1993; 192(1):241-5

Diabetes

Field

Title

Author

Journal

1	Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes.	Hodgson JM, et al.	Eur. J. Clin. Nutr. 2002; 56(11):1137-42
2	Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type 2 diabetes mellitus.	Watts GF, et al.	Diabetologia. 2002; 45(3):420-6
3	The effect of coenzyme Q10 administration on metabolic control type 2 diabetes mellitus.	Eriksson JG, et al.	Biofactors. 1999; 9(2-4):315-8
4	Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with Type 1 diabetes mellitus.	Henriksen JE, et al.	Diabet. Med. 1999; 16(4):312-8
5	The effect of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation.	Suzuki S, et al.	Diabetologia. 1998; 41(5):584-8
6	Plasma ubiquinol/cholesterol ratios in patients with hyperlipidaemia, those with diabetes mellitus and in patients requiring dialysis.	McDonnell MG, et al.	Clin. Chim. Acta. 1996; 253(1-2):117-26

Energy

Field

Title

Author

Journal

2	Biochemical functions of coenzyme Q10.	Crane FL..	J. Am. Coll. Nutr. 2001; 20(6):591-8
3	Coenzyme Q: potentially useful index of bioenergetic and oxidative status of spermatozoa.	Angelitti AG, et al.	Clin. Chem. 1995; 41(2):217-9

Friedreich’s Ataxia

Field

Title

Author

Journal

1	Coenzyme Q10 and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits.	Geromel V, et al.	Mol. Genet. Metab. 2002; 77(1-2):21-30
2	Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia.	Lodi R, et al.	Ann. Neurol. 2001; 49(5):590-6

Heart Disease

Field

Title

Author

Journal

1	Role of coenzyme Q10 in chronic heart failure, angina, and hypertension.	Tran MT, et al.	Pharmacotherapy. 2001; 21(7):797-806
2	Coenzyme Q10 treatment in serious heart failure.	Munkholm H, et al.	Biofactors. 1999; 9(2-4):285-9
3	Overview of the use of CoQ10 in cardiovascular disease.	Langsjoen PH, et al.	Biofactors. 1999; 9(2-4):273-84
4	Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group.	Hofman-Bang C, et al.	J. Card. Fail. 1995; 1(2):101-7
5	Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study.	Morisco C, et al.	Clin. Investig. 1993; 71(8 Suppl):s134-6
6	A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10.	Langsjoen PH, et al.	Int. J. Tissue React. 1990; 12(3):169-71
7	Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10.	Folkers K, et al.	Proc. Natl. Acad. Sci. U. S. A. 1985; 82(3):901-4

High Blood Pressure (Hypertension)

Field

Title

Author

Journal

1	Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes.	Hodgson JM, et al.	Eur. J. Clin. Nutr. 2002; 56(11):1137-42
2	Treatment of essential hypertension with coenzyme Q10.	Langsjoen P, et al.	Mol. Aspects Med. 1994; 15 Suppl:s265-72

Huntington's Disease

Field

Title

Author

Journal

1	Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.	Ferrante RJ, et al.	J. Neurosci. 2002; 22(5):1592-9
2	A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease.	Huntington Study Group.	Neurology. 2001; 57(3):397-404
3	Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.	Koroshetz WJ, et al.	Ann. Neurol. 1997; 41(2):160-5

Immune System

Field

Title

Author

Journal

1	Coenzyme Q10 in vesicles composed of archaeal ether lipids or conventional lipids enhances the immuno-adjuvanticity to encapsulated protein.	Makabi-Panzu B, et al.	Vaccine. 1998; 16(16):1504-10
2	The activities of coenzyme Q10 and vitamin B6 for immune responses	Folkers K, et al.	Biochem. Biophys. Res. Commun. 1993; 193(1):88-92

Muscular Dystrophy

Field

Title

Author

Journal

1	Coenzyme Q10, exercise lactate and CTG trinucleotide expansion in myotonic dystrophy.	Siciliano G, et al.	Brain Res. Bull. 2001; 56(3-4):405-10
2	Potential involvement of ubiquinone in myotonic dystrophy pathophysiology: new diagnostic approaches for new rationale therapeutics.	Tedeschi D, et al.	Neurol. Sci. 2000; 21(5 Suppl):s979-80
3	Two successful double-blind trials with coenzyme Q10 muscular dystrophies and neurogenic atrophies.	Folkers K, et al.	Biochim. Biophys. Acta. 1995; 1271(1):281-6

Parkinson's Disease

Field

Title

Author

Journal

1	Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease.	Muller T, et al.	Neurosci. Lett. 2003; 341(3):201-4
2	Effects of Coenzyme Q10 in Early Parkinson Disease: evidence of slowing of the functional decline.	Shults CW, et al.; Parkinson Study Group	Arch. Neurol. 2002; 59(10):1541-50

Periodontal Disease

Field

Title

Author

Journal

1	Coenzyme Q10 and periodontal treatment: is there any beneficial effect?	Watts TL, et al.	Br. Dent. J. 1995; 178(6):209-13
2	Effect of topical application of coenzyme Q10 on adult periodontitis.	Hanioka T, et al.	Mol. Aspects Med. 1994; 15 Suppl:s241-8
3	Therapy with coenzyme Q10 for patients with periodontal disease	Mcree JT, et al.	J. Dent. Heal. 1993; 43:659-66
4	Clinical effect of coenzyme Q10 on periodontal disease.	Iwamoto Y, et al.	in Biomedical and Clinical Aspects of CoQ: Elsevier 1981; 3:109-19
5	Bioenergetics in clinical medicine.VI. adjunctive treatment of periodontal disease with coenzyme Q10.	Wilkinson EG, et al.	Res. Commun. Chem. Pathol. Pharmacol. 1976; 14(4):715-9

Statins

Field

Title

Author

Journal

1	Statins and coenzyme Q10.	Ellis CJ, et al.	Lancet 2003; 361(9363):1134-5
2	ACC/AHA/NHLBI clinical advisory on the use and safety of statins.	Pasternak RC, et al.	J. Am. Coll. Cardiol. 2002; 40(3):567-72
3	Statins and myopathy.	Hargreaves IP, et al.	Lancet 2002; 359(9307):711-2
4	Biochemical and clinical consequences of inhibiting CoQ10 biosynthesis by lipid-lowering HMG-CoA reductase inhibitors (statins): a critical overview	Bliznakov EG, et al.	Adv. Ther. 1998; 15(4):218-28
5	Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study.	Ghirlanda G, et al.	J. Clin. Pharmacol. 1993; 33(3):226-9

Sporting Activity

Field

Title

Author

Journal

1	Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects.	Bonetti A, et al.	J. Sports Med. Phys. Fitness. 2000; 40(1):51-7
2	Effects of ubiquinone-10 supplementation and high intensity training on physical performance in humans.	Malm C, et al.	Acta Physiol. Scand. 1997; 161(3):379-84
3	Ubiquinone supplementation and exercise capacity in trained young and older men.	Laaksonen R, et al.	Eur. J. Appl. Physiol. Occup. Physiol. 1995; 72(1-2):95-100
4	Influence of coenzyme-Q10 on physical work capacity in athletes, sedentary people and patients with mitochondrial disease.	Zeppili P, et al.	in Biomedical and Clinical Aspects of CoQ: Elsevier. 1991; 6:541-5
5	Effect of CoQ10 on the Metabolic Response to Work.	Cerioli G, et al.	in Biomedical and Clinical Aspects of CoQ: Elsevier. 1991; 6:521-4
6	Metabolic effects of coenzyme Q10 treatment in high level athletes.	Fiorella PL, et al.	in Biomedical and Clinical Aspects of CoQ: Elsevier. 1991; 6:513-20

NOTICE: The foregoing descriptions and data concerning clinical testing and studies with regard to Coenzyme Q10 ("CoQ10") are based upon information available or provided to Kaneka Nutrients L.P. and are considered to be substantiated and reliable.

The descriptions and data included herein is not intended to be a diagnosis of any medical condition, advice concerning any illness or medical condition, or claim as to the efficacy of CoQ10 to prevent, treat or cure any disease or medical condition.

The U.S. Food and Drug Administration has approved CoQ10 for use and consumption as a dietary supplement. Consult your physician to diagnosis and treat of your specific medical condition and any personal illness.